Pub. Date : 2020
PMID : 33195437
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 2 | Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 3 | Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 4 | Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 5 | Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 6 | Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 7 | The current review highlights FK506/rapamycin-FKBP12 interactions with calcineurin/TOR kinase in human and fungi, and development of non-immunosuppressive analogs of FK506, rapamycin, and novel small molecules in inhibition of fungal calcineurin and TOR kinase. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |