Pub. Date : 2020 Nov 13
PMID : 33185690
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A growing body of evidence is demonstrating a detrimental role of CYP1B1 in both cardiovascular diseases and cancer, via perturbed metabolism of endogenous compounds, production of carcinogenic metabolites, DNA adduct formation, and generation of reactive oxygen species (ROS). | Reactive Oxygen Species | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | A growing body of evidence is demonstrating a detrimental role of CYP1B1 in both cardiovascular diseases and cancer, via perturbed metabolism of endogenous compounds, production of carcinogenic metabolites, DNA adduct formation, and generation of reactive oxygen species (ROS). | Reactive Oxygen Species | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | Several chemotherapeutic agents have been shown to induce CYP1B1 in cardiovascular and cancer cells, possibly via activating the Aryl hydrocarbon Receptor (AhR), ROS generation, and inflammatory cytokines. | Reactive Oxygen Species | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |