Pub. Date : 2020 Nov 13
PMID : 33185189
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SARM1 an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | This inactive conformation is stabilized by binding of SARM1"s own substrate NAD+ in an allosteric location, away from the catalytic sites. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | We propose that the reduction of cellular NAD+ concentration contributes to the disassembly of SARM1"s peripheral ring, which allows formation of active NADase domain dimers, thereby further depleting NAD+ to cause an energetic catastrophe and cell death. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 4 | We propose that the reduction of cellular NAD+ concentration contributes to the disassembly of SARM1"s peripheral ring, which allows formation of active NADase domain dimers, thereby further depleting NAD+ to cause an energetic catastrophe and cell death. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |