Title : Lactate Exposure Promotes Immunosuppressive Phenotypes in Innate Immune Cells.

Pub. Date : 2020 Oct

PMID : 33184582






1 Functional Relationships(s)
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1 MCT4 inhibition significantly boosted lactate M2 polarization, while blocking of MCT1/2 failed to reverse the immunosuppressive effect of lactate, correlating with the result of gene expression that lactate increased MCT4 expression, but downregulated the expression of MCT1/2. Lactic Acid solute carrier family 16 member 3 Homo sapiens