Pub. Date : 2021 Jan
PMID : 33184150
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long-Term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes. | Sulfonylurea Compounds | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 2 | OBJECTIVE: ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ~90% of individuals can be treated with oral sulfonylureas instead of insulin. | Sulfonylurea Compounds | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 3 | Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. | Sulfonylurea Compounds | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 4 | We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated ABCC8-PNDM. | Sulfonylurea Compounds | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 5 | CONCLUSIONS: Sulfonylurea treatment of ABCC8-PNDM results in excellent long-term glycemic control. | Sulfonylurea Compounds | ATP binding cassette subfamily C member 8 | Homo sapiens |