Title : Design, synthesis and evaluation of calix[4]arene-based carbonyl amide derivatives with antitumor activities.

Pub. Date : 2021 Jan 15

PMID : 33183867






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further mechanism studies significantly indicated that compound 5h could block MDA-MB-231 cell cycle arrest in G0/G1 phase by down regulating cyclin D1 and CDK4, and induce apoptosis by up-regulation of Bax, down-regulation of Caspase-3, PARP and Bcl-2 proteins, resulting in the reduction of DNA synthesis and cell division arrest. 5h collagen type XI alpha 2 chain Homo sapiens