Pub. Date : 2020 Nov
PMID : 33182048
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Emodin improves alveolar hypercoagulation and inhibits pulmonary inflammation in LPS-provoked ARDS in mice via NF-kappaB inactivation. | Emodin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Emodin, a traditional Chinese herb, shows potent inhibitory effect on NF-kappaB pathway, but whether it is effective in alveolar hypercoagulation and pulmonary inflammation in ARDS remains to be elucidated. | Emodin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Meanwhile, emodin effectively inhibited NF-kappaB pathway activation and attenuated p65 DNA binding activity induced by LPS inhalation. | Emodin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 4 | CONCLUSIONS: Emodin improves alveolar hypercoagulation and fibrinolytic inhibition and depresses excessive pulmonary inflammation in ARDS mice in dose-dependent manner via NF-kappaB inactivation. | Emodin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |