Title : Stroma secreted IL6 selects for "stem-like" population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways.

Pub. Date : 2020 Nov 11

PMID : 33177492






1 Functional Relationships(s)
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1 Additionally, the stromal fibroblasts secrete IL6 as the major cytokine, increases glycolytic flux in the pancreatic tumor cells, and increases lactate efflux in the microenvironment via activation of the STAT signaling pathway. Lactic Acid interleukin 6 Homo sapiens