Pub. Date : 2020
PMID : 33176649
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: This study aimed to investigate whether curcumin changed microglia to an anti-inflammatory M2-phenotype by activating the AMP-activated protein kinase (AMPK) signaling pathway. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 2 | RESULTS: Curcumin enhanced AMPK activation in BV2 microglial cells in the presence and absence of LPS. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 3 | The effects of curcumin were inhibited by an AMPK inhibitor or AMPK knockdown. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 4 | The effects of curcumin were inhibited by an AMPK inhibitor or AMPK knockdown. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 5 | Curcumin can activate AMPK in Hela cells, which do not express LKB1. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 6 | However, both the CaMKKbeta inhibitor and siRNA blocked curcumin activation of AMPK in LPS-stimulated BV2 cells. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 7 | Finally, curcumin enhanced AMPK activation in the brain area where microglia were over-activated upon LPS stimulation in an in vivo neuroinflammation model. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 8 | CONCLUSION: Curcumin enhances microglia M2 polarization via the CaMKKbeta-dependent AMPK signaling pathway. | Curcumin | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |