Pub. Date : 2020 Dec
PMID : 33173974
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/beta-catenin signaling pathway. | Capsaicin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, capsaicin significantly reduced the expression levels of phosphorylated (p)-PI3K, p-Akt, Wnt and beta-catenin in vitro compared with the control group. | Capsaicin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Collectively, the results of the present study suggested that capsaicin inhibited breast cancer cell viability, induced G2/M cell cycle arrest, reduced CDK8 expression levels, decreased the phosphorylation of PI3K and Akt and downregulated Wnt and beta-catenin expression levels in MDA-MB-231 cells. | Capsaicin | AKT serine/threonine kinase 1 | Homo sapiens |