Title : The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.

Pub. Date : 2021 Feb

PMID : 33173151






1 Functional Relationships(s)
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1 Combining the clinically used TOP1 inhibitor topotecan with CX-5461 potentiates a G2/M cell cycle checkpoint arrest in multiple HR-proficient HGSC cell lines. Topotecan DNA topoisomerase I Homo sapiens