Title : Renoprotective and haemodynamic effects of adiponectin and peroxisome proliferator-activated receptor agonist, pioglitazone, in renal vasculature of diabetic Spontaneously hypertensive rats.

Pub. Date : 2020

PMID : 33170841






3 Functional Relationships(s)
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1 Pioglitazone, a therapeutic drug for diabetes, possesses full PPAR-gamma agonist activity and increase circulating adiponectin plasma concentration. Pioglitazone adiponectin, C1Q and collagen domain containing Rattus norvegicus
2 Adiponectin significantly blunted responses to NA, PE, ME and ANG II in diabetic treated SHRs by 40%, whereas the pioglitazone combined therapy with adiponectin further attenuated the responses to adrenergic agonists by 65%. Pioglitazone adiponectin, C1Q and collagen domain containing Rattus norvegicus
3 These findings suggest that adiponectin possesses renoprotective effects and improves renal haemodynamics through adiponectin receptors and PPAR-gamma in diabetic SHRs, suggesting that synergism exists between adiponectin and pioglitazone. Pioglitazone adiponectin, C1Q and collagen domain containing Rattus norvegicus