Pub. Date : 2021 Jan 4
PMID : 33170804
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In spinal and bulbar muscular atrophy (SBMA), polyQ expansion within the androgen receptor (AR) causes progressive neuromuscular toxicity, the molecular basis of which is unclear. | polyglutamine | androgen receptor | Mus musculus |
| 2 | In spinal and bulbar muscular atrophy (SBMA), polyQ expansion within the androgen receptor (AR) causes progressive neuromuscular toxicity, the molecular basis of which is unclear. | polyglutamine | androgen receptor | Mus musculus |
| 3 | Using quantitative proteomics, we identified changes in the AR interactome caused by polyQ expansion. | polyglutamine | androgen receptor | Mus musculus |
| 4 | We found that the deubiquitinase USP7 preferentially interacts with polyQ-expanded AR, and that lowering USP7 levels reduced mutant AR aggregation and cytotoxicity in cell models of SBMA. | polyglutamine | androgen receptor | Mus musculus |