Title : Drug repurposing for Alzheimer's disease: in silico and in vitro investigation of FDA-approved drugs as acetylcholinesterase inhibitors.

Pub. Date : 2022 Apr

PMID : 33170091






5 Functional Relationships(s)
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1 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine acetylcholinesterase (Cartwright blood group) Homo sapiens
4 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine acetylcholinesterase (Cartwright blood group) Homo sapiens
5 On the basis of our computational and experimental studies, it can be suggested that the beneficial effect of RGZ and HCQ in AD patients reported in the literature may partly be due to their AChE inhibitory property. Hydroxychloroquine acetylcholinesterase (Cartwright blood group) Homo sapiens