Pub. Date : 2020 Nov 10
PMID : 33167868
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression. | Arecoline | early growth response 1 | Homo sapiens |
| 2 | Treatment with siRNAs specific to Egr-1, Egr inhibitors, or Wnt5a antibody treatment could all inhibit arecoline-induced Wnt5a upregulation and fibroblast proliferation. | Arecoline | early growth response 1 | Homo sapiens |
| 3 | CONCLUSIONS: Egr-1 mediates the effect of low dose arecoline treatment on human oral mucosa fibroblast proliferation by transactivating the expression of Wnt5a. | Arecoline | early growth response 1 | Homo sapiens |