Pub. Date : 2021 Apr
PMID : 33165749
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 2 | Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 3 | We demonstrated here that Vav1 sustains the maturation to beta-cells of the normal precursors human Biliary Tree Stem/progenitor Cells (hBTSCs) induced by a differentiation medium containing ATRA and that, in the mature normal pancreas, insulin-producing cells express variable levels of Vav1. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 4 | Using pancreatic ductal adenocarcinoma (PDAC)-derived cells, we also revealed that the ATRA induced up-modulation of Vav1 is essential for the retinoid-induced trans-differentiation of neoplastic cells into insulin producing cells. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 5 | The results of this study identify Vav1 as crucial molecule in ATRA induced maturation of insulin producing cells and suggest this protein as a marker for new strategies ended to restore functional beta-cells. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |