Title : c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder.

Pub. Date : 2020 Nov 20

PMID : 33163944






1 Functional Relationships(s)
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1 Here, we show that under pharmacological and genetic c-Abl inhibition, TFEB translocates into the nucleus promoting the expression of its target genes independently of its well-known regulator, mammalian target of rapamycin complex 1. Sirolimus transcription factor EB Homo sapiens