Title : Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth.

Pub. Date : 2021 Jan 15

PMID : 33158816






4 Functional Relationships(s)
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1 Pharmacological inhibition of GRK2 by the clinically approved antidepressant, serotonin reuptake inhibitor paroxetine (PX), recapitulated the effects of GRK2-silencing with dose- and time-dependent IGF-1R downregulation without associated beta-arr-BS. Paroxetine G protein-coupled receptor kinase 2 Homo sapiens
2 Pharmacological inhibition of GRK2 by the clinically approved antidepressant, serotonin reuptake inhibitor paroxetine (PX), recapitulated the effects of GRK2-silencing with dose- and time-dependent IGF-1R downregulation without associated beta-arr-BS. Paroxetine G protein-coupled receptor kinase 2 Homo sapiens
3 Pharmacological inhibition of GRK2 by the clinically approved antidepressant, serotonin reuptake inhibitor paroxetine (PX), recapitulated the effects of GRK2-silencing with dose- and time-dependent IGF-1R downregulation without associated beta-arr-BS. Paroxetine G protein-coupled receptor kinase 2 Homo sapiens
4 Pharmacological inhibition of GRK2 by the clinically approved antidepressant, serotonin reuptake inhibitor paroxetine (PX), recapitulated the effects of GRK2-silencing with dose- and time-dependent IGF-1R downregulation without associated beta-arr-BS. Paroxetine G protein-coupled receptor kinase 2 Homo sapiens