Pub. Date : 2020 Dec 15
PMID : 33157119
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown that 4-methylpyrazole (4MP, Fomepizole) protects against APAP-induced liver injury by inhibiting reactive metabolite formation through Cyp2E1, and analysis of data from APAP overdose patients indicated that kidney dysfunction strongly correlated with severe liver injury. | Fomepizole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 2 | We have shown that 4-methylpyrazole (4MP, Fomepizole) protects against APAP-induced liver injury by inhibiting reactive metabolite formation through Cyp2E1, and analysis of data from APAP overdose patients indicated that kidney dysfunction strongly correlated with severe liver injury. | Fomepizole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 3 | We have shown that 4-methylpyrazole (4MP, Fomepizole) protects against APAP-induced liver injury by inhibiting reactive metabolite formation through Cyp2E1, and analysis of data from APAP overdose patients indicated that kidney dysfunction strongly correlated with severe liver injury. | Fomepizole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 4 | Since Cyp2E1 is also expressed in the kidney, this study explored protection by 4MP against APAP-induced nephrotoxicity. | Fomepizole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |