Title : Chrono-optimization of the time of evening administration with unequally divided twice-daily theophylline.

Pub. Date : 1987

PMID : 3315266






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1 However, the concomitant requirement for corticosteroids and inhaled beta-2-mimetics complicates the assessment of the relative clinical efficacy of the major dosing of theophylline during the 24 hr even though this drug is usually not given as a monotherapy in severe patients with reversible airway obstruction. Theophylline potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens