Title : Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.

Pub. Date : 2021 Jan

PMID : 33152664






1 Functional Relationships(s)
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1 In vivo pharmacological inhibition of COX-2 by celecoxib decreased tissue fibrosis and increased skeletal muscle fiber preservation reflected by less ECM formation and myofibroblast accumulation with decreased p-ERK1/2, p-Smad2/3, TGF-betaR1, VEGF, NOX2 and NOX4 expression. Celecoxib mitogen-activated protein kinase 3 Homo sapiens