Pub. Date : 2020 Nov
PMID : 33152658
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of HBCs with both LPS and ATP induced the rapid secretion of high levels of IL-1beta and at the same time, cell death associated with nuclear condensation and cellular swelling. | Adenosine Triphosphate | interleukin 1 alpha | Homo sapiens |
| 2 | HBC treatment with both LPS and ATP induced caspase-1 activation, gasdermin D (GSDMD) cleavage, which mediates pyroptosis, and IL-1beta processing. | Adenosine Triphosphate | interleukin 1 alpha | Homo sapiens |
| 3 | Together, our data indicate that LPS and ATP treatment stimulated NLRP3 inflammasome activation and pyroptosis in HBCs leading to the rapid release of IL-1beta. | Adenosine Triphosphate | interleukin 1 alpha | Homo sapiens |