Pub. Date : 2021 May
PMID : 33151424
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells. | Paclitaxel | zinc finger E-box binding homeobox 1 | Homo sapiens |
| 2 | RESULTS: ZEB1-AS1 depletion using siRNA in chemosensitive A2780 cells significantly increased PTX and DDP resistance. | Paclitaxel | zinc finger E-box binding homeobox 1 | Homo sapiens |
| 3 | In contrast, ZEB1-AS1 overexpression in PTX- and DDP-resistant A2780/resistant (A2780/R) cells reversed the observed drug resistance. | Paclitaxel | zinc finger E-box binding homeobox 1 | Homo sapiens |
| 4 | Thus, ZEB1-AS1 plays an important role in PTX and DDP resistance in EOC cells. | Paclitaxel | zinc finger E-box binding homeobox 1 | Homo sapiens |
| 5 | CCK8 assay results suggested that MMP19 knockdown promoted ZEB1-AS1-induced chemoresistance to PTX and DDP in A2780 cells. | Paclitaxel | zinc finger E-box binding homeobox 1 | Homo sapiens |