Pub. Date : 2020
PMID : 33149614
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, after zeaxanthin treatment, the expression levels of reactive oxygen species (ROS), p-JNK, p-p38, and I-kappaB increased, and the expression levels of p-ERK, p-AKT, STAT3, and NF-kappaB decreased. | Zeaxanthins | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | However, the ROS scavenger N-acetylcysteine (NAC) and MAPK inhibitors inhibited zeaxanthin-induced apoptosis, and under the action of zeaxanthin, MAPK regulated NF-kappaB and STAT3, and reduced their protein expression levels. | Zeaxanthins | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Conclusion: Zeaxanthin has a potential effect against gastric cancer cells through the ROS-mediated MAPK, AKT, NF-kappaB, and STAT3 signaling pathways, and it is expected to become a new drug for the treatment of human gastric cancer. | Zeaxanthins | nuclear factor kappa B subunit 1 | Homo sapiens |