Pub. Date : 2021 Jan 1
PMID : 33148422
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY FINDINGS: Here, we revealed that overexpressed FGFR1 and its downstream AKT/mTOR and ERK signaling activation could induce lenvatinib resistance in HCC. | lenvatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Mechanism studies revealed that Oxysophocarpine downregulated FGFR1 expression along with downstream AKT/mTOR and ERK signaling to sensitize lenvatinib against FGFR1-overexpressed HCC. | lenvatinib | AKT serine/threonine kinase 1 | Homo sapiens |