Title : Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro.

Pub. Date : 2021 Feb

PMID : 33146575






1 Functional Relationships(s)
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1 Further in vitro inhibition experiments showed that multiple non-CYP enzymes are involved in the formation of 6-MNA from 3-OH-NAB. 6-methoxy-2-naphthylacetic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens