Title : Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro.

Pub. Date : 2021 Feb

PMID : 33146575






2 Functional Relationships(s)
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1 Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy-nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. 6-methoxy-2-naphthylacetic acid flavin containing dimethylaniline monoxygenase 5 Homo sapiens
2 6-MNA was also detected in the extract obtained from 3-OH-NAB by a combined incubation of recombinant human FMO5 and human liver S9. 6-methoxy-2-naphthylacetic acid flavin containing dimethylaniline monoxygenase 5 Homo sapiens