Pub. Date : 2020 Oct 28
PMID : 33145420
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The native substrate of Cp is Fe2+. | ammonium ferrous sulfate | ceruloplasmin | Homo sapiens |
| 2 | In human serum, Cp operates under substrate-limiting low [Fe2+] but high [O2] conditions, implying the possible involvement of partially reduced intermediates in Cp catalysis. | ammonium ferrous sulfate | ceruloplasmin | Homo sapiens |
| 3 | Our results lead to a new hypothesis that human iron transport is regulated as the paired transfer of iron from ferroportin to Cp to transferrin, and the tyrosine residue in Cp acts as a gate to avoid reactive oxygen species (ROS) formation when Fe2+ delivery is dysregulated. | ammonium ferrous sulfate | ceruloplasmin | Homo sapiens |