Pub. Date : 2020 Nov 3
PMID : 33144310
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages. | Fatty Acids, Volatile | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | Mus musculus |
| 2 | Oral supplementation with gut microbiota-derived short-chain fatty acids (SCFAs), subsequently activating G protein-coupled receptor 43 (GPCR43), enhances a macrophage"s capacity to phagocytose invading K. pneumoniae Furthermore, SCFAs and GPR43 increase macrophage bacterial clearance by upregulating LAMTOR2, which is further identified as an antibacterial effector and elucidated to facilitate phagosome-lysosome fusion and extracellular signal-regulated kinase (ERK) phosphorylation. | Fatty Acids, Volatile | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | Mus musculus |
| 3 | Lastly, conditional ablation of Lamtor2 in macrophages decreases their antimicrobial activity, even though mice were pretreated with exogenous SCFA supplementation.IMPORTANCE These observations highlight that SCFAs promote macrophage elimination of K. pneumoniae via a LAMTOR2-dependent signal pathway and suggest that it is possible to intervene in K. pneumoniae pneumonia by targeting the gut microbiota. | Fatty Acids, Volatile | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | Mus musculus |