Pub. Date : 2020 Nov 2
PMID : 33139730
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. | Tamoxifen | cyclin D1 | Homo sapiens |
| 2 | Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. | Tamoxifen | cyclin D1 | Homo sapiens |
| 3 | High expression of DILA1 is associated with overexpressed Cyclin D1 protein and poor prognosis in breast cancer patients who received tamoxifen treatment. | Tamoxifen | cyclin D1 | Homo sapiens |
| 4 | This study shows the previously unappreciated importance of post-translational dysregulation of Cyclin D1 contributing to tamoxifen resistance in breast cancer. | Tamoxifen | cyclin D1 | Homo sapiens |
| 5 | Moreover, it reveals the novel mechanism of DILA1 in regulating Cyclin D1 protein stability and suggests DILA1 is a specific therapeutic target to downregulate Cyclin D1 protein and reverse tamoxifen resistance in treating breast cancer. | Tamoxifen | cyclin D1 | Homo sapiens |