Title : Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system.

Pub. Date : 2020 Oct

PMID : 33133730






4 Functional Relationships(s)
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1 Herein, facilitated by a selective and sensitive fluorescence probe, we observed that some NO modulators displayed unexpected behaviors with both NO scavenger carboxy-PTIO and endothelial nitric oxide synthase (eNOS) inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME) failing to decrease intracellular free NO level in EA. NG-Nitroarginine Methyl Ester nitric oxide synthase 3 Homo sapiens
2 Herein, facilitated by a selective and sensitive fluorescence probe, we observed that some NO modulators displayed unexpected behaviors with both NO scavenger carboxy-PTIO and endothelial nitric oxide synthase (eNOS) inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME) failing to decrease intracellular free NO level in EA. NG-Nitroarginine Methyl Ester nitric oxide synthase 3 Homo sapiens
3 Herein, facilitated by a selective and sensitive fluorescence probe, we observed that some NO modulators displayed unexpected behaviors with both NO scavenger carboxy-PTIO and endothelial nitric oxide synthase (eNOS) inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME) failing to decrease intracellular free NO level in EA. NG-Nitroarginine Methyl Ester nitric oxide synthase 3 Homo sapiens
4 Herein, facilitated by a selective and sensitive fluorescence probe, we observed that some NO modulators displayed unexpected behaviors with both NO scavenger carboxy-PTIO and endothelial nitric oxide synthase (eNOS) inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME) failing to decrease intracellular free NO level in EA. NG-Nitroarginine Methyl Ester nitric oxide synthase 3 Homo sapiens