Title : Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms.

Pub. Date : 2021 Feb 8

PMID : 33131992






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1 Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms. Insulin Glargine insulin Homo sapiens
2 Preliminary evidence for peptide uptake by the gut has recently been obtained, by our research group, following the administration of nanostructured lipid-carrier suspensions loaded with glargine insulin in healthy animal models. Insulin Glargine insulin Homo sapiens
3 METHODS AND RESULTS: In this experimental study, glargine insulin-loaded nanostructured lipid carriers have been converted into solid oral dosage forms (tablets, capsules), that are more suitable for administration in humans and have prolonged shelf-life. Insulin Glargine insulin Homo sapiens
4 A suitable composition gave redispersible solid oral dosage forms from glargine insulin-loaded carriers, using both spray-drying and freeze-drying. Insulin Glargine insulin Homo sapiens