Title : Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia.

Pub. Date : 2021 Jan

PMID : 33129109






1 Functional Relationships(s)
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1 Combinations of Upadacitinib with either AZD8055 or Sapanisertib, mTORC1/C2 inhibitors, showed anti-proliferative effects against cytokine-dependent ATL cell lines and synergistic effect with reducing tumor growth in NSG mice bearing IL-2 transgenic tumors. upadacitinib CREB regulated transcription coactivator 1 Mus musculus