Pub. Date : 2020
PMID : 33123534
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 2 | Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 3 | Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 4 | Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 5 | Mechanistically, caffeine directly binds to G6PDH with high affinity (K D = 0.1923 muM) and competes with the coenzyme NADP+ for G6PDH binding, as demonstrated by the decreased binding affinities of G6PDH for its coenzyme and substrate. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 6 | Mechanistically, caffeine directly binds to G6PDH with high affinity (K D = 0.1923 muM) and competes with the coenzyme NADP+ for G6PDH binding, as demonstrated by the decreased binding affinities of G6PDH for its coenzyme and substrate. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 7 | Molecular docking studies revealed that caffeine binds to G6PDH at the structural NADP+ binding site, and chemical cross-linking analysis demonstrated that caffeine inhibits the formation of dimeric G6PDH. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |
| 8 | Moreover, inhibition of G6PDH activity by caffeine led to a reduction in the intracellular levels of NADPH and reactive oxygen species (ROS), and altered the expression of redox-related proteins in RCC cells. | NADP | glucose-6-phosphate dehydrogenase | Homo sapiens |