Title : Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling.

Pub. Date : 2020

PMID : 33123172






3 Functional Relationships(s)
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1 Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-kappaB Activation via GPR81-Mediated Signaling. Lactic Acid hydroxycarboxylic acid receptor 1 Homo sapiens
2 Importantly, lactate suppressed YAP activation and nuclear translocation is mediated by GPR81 dependent AMKP and LATS activation which phosphorylates YAP, resulting in YAP inactivation. Lactic Acid hydroxycarboxylic acid receptor 1 Homo sapiens
3 Our study demonstrates that lactate exerts a previously unknown role in the suppression of macrophage pro-inflammatory cytokine production via GPR81 mediated YAP inactivation, resulting in disruption of YAP and NF-kappaB interaction and nuclear translocation in macrophages. Lactic Acid hydroxycarboxylic acid receptor 1 Homo sapiens