Pub. Date : 2020
PMID : 33123172
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-kappaB Activation via GPR81-Mediated Signaling. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
2 | Importantly, lactate suppressed YAP activation and nuclear translocation is mediated by GPR81 dependent AMKP and LATS activation which phosphorylates YAP, resulting in YAP inactivation. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
3 | Our study demonstrates that lactate exerts a previously unknown role in the suppression of macrophage pro-inflammatory cytokine production via GPR81 mediated YAP inactivation, resulting in disruption of YAP and NF-kappaB interaction and nuclear translocation in macrophages. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |