Pub. Date : 2020
PMID : 33117724
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling. | ipah4 | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Here, we demonstrate that IpaH4.5, a Shigella T3SS effector, triggers inflammasome activation by regulating NLRP3 expression through the E3 ubiquitin ligase activity of IpaH4.5. | ipah4 | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Here, we demonstrate that IpaH4.5, a Shigella T3SS effector, triggers inflammasome activation by regulating NLRP3 expression through the E3 ubiquitin ligase activity of IpaH4.5. | ipah4 | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | First, we found that IpaH4.5 interacted with NLRP3. | ipah4 | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | As a result, IpaH4.5 modulated NLRP3 protein stability and inflammasome activation. | ipah4 | NLR family pyrin domain containing 3 | Homo sapiens |