Title : Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma.

Pub. Date : 2020 Oct 28

PMID : 33116117






2 Functional Relationships(s)
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1 Furthermore, results showed that the stemness inhibition by metformin was associated with blockade of the IL6-stat3 axis. Metformin interleukin 6 Homo sapiens
2 Survival analysis demonstrated that overexpression of IL6 and stemness markers was associated with poor survival in HNSCC patients, indicating that including metformin to target these proteins might improve patient prognosis. Metformin interleukin 6 Homo sapiens