Title : Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy.

Pub. Date : 2020 Oct 26

PMID : 33114586






3 Functional Relationships(s)
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1 Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy. Magnesium transient receptor potential cation channel subfamily M member 6 Homo sapiens
2 Our findings demonstrate that TRPM6 is the key channel that mediates Mg influx in intestinal cells and that EGF stimulates such influx; consequently, CTX downregulates TRPM6-mediated Mg influx by interfering with EGF signaling. Magnesium transient receptor potential cation channel subfamily M member 6 Homo sapiens
3 Our findings demonstrate that TRPM6 is the key channel that mediates Mg influx in intestinal cells and that EGF stimulates such influx; consequently, CTX downregulates TRPM6-mediated Mg influx by interfering with EGF signaling. Magnesium transient receptor potential cation channel subfamily M member 6 Homo sapiens