Title : Effect of valproic acid on the hepatic differentiation of mesenchymal stem cells in 2D and 3D microenvironments.

Pub. Date : 2021 Feb

PMID : 33111212






2 Functional Relationships(s)
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1 Our results demonstrate that MSCs differentiate into hepatic-like cells when treated with 5 mM VPA for 24 h. The VPA-treated MSCs have shown significant upregulation in the expression of hepatic genes, CK-18 (P < 0.05), TAT (P < 0.01), and AFP (P < 0.001), and hepatic proteins, AFP (P < 0.05) and ALB (P < 0.01). Valproic Acid albumin Homo sapiens
2 Our results demonstrate that MSCs differentiate into hepatic-like cells when treated with 5 mM VPA for 24 h. The VPA-treated MSCs have shown significant upregulation in the expression of hepatic genes, CK-18 (P < 0.05), TAT (P < 0.01), and AFP (P < 0.001), and hepatic proteins, AFP (P < 0.05) and ALB (P < 0.01). Valproic Acid albumin Homo sapiens