Pub. Date : 2020 Dec 25
PMID : 33109600
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 2 | In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 3 | Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 4 | Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 5 | Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 6 | Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 7 | Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 8 | Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Delta1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 9 | Many cancers alter their proline metabolism by upregulating the proline cycle and proline biosynthesis, and knockdowns of PYCR1 lead to decreased cell proliferation. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 10 | NFLP was also shown to phenocopy the PYCR1knockdown in MCF10A H-RASV12 breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 11 | In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 12 | In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |