Title : A novel germline variant in RET gene resulting in an additional cysteine in a family with familial medullary thyroid carcinoma.

Pub. Date : 2021 Jul

PMID : 33084974






9 Functional Relationships(s)
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1 A novel germline variant in RET gene resulting in an additional cysteine in a family with familial medullary thyroid carcinoma. Cysteine ret proto-oncogene Homo sapiens
2 Variants are frequently located in the RET extracellular cysteine-rich region domain, mainly affecting cysteines which are replaced by an alternative amino acid, resulting in a mispaired cysteine and the generation of RET dimers. Cysteine ret proto-oncogene Homo sapiens
3 Variants are frequently located in the RET extracellular cysteine-rich region domain, mainly affecting cysteines which are replaced by an alternative amino acid, resulting in a mispaired cysteine and the generation of RET dimers. Cysteine ret proto-oncogene Homo sapiens
4 Variants are frequently located in the RET extracellular cysteine-rich region domain, mainly affecting cysteines which are replaced by an alternative amino acid, resulting in a mispaired cysteine and the generation of RET dimers. Cysteine ret proto-oncogene Homo sapiens
5 Variants are frequently located in the RET extracellular cysteine-rich region domain, mainly affecting cysteines which are replaced by an alternative amino acid, resulting in a mispaired cysteine and the generation of RET dimers. Cysteine ret proto-oncogene Homo sapiens
6 Variants are frequently located in the RET extracellular cysteine-rich region domain, mainly affecting cysteines which are replaced by an alternative amino acid, resulting in a mispaired cysteine and the generation of RET dimers. Cysteine ret proto-oncogene Homo sapiens
7 Variants are frequently located in the RET extracellular cysteine-rich region domain, mainly affecting cysteines which are replaced by an alternative amino acid, resulting in a mispaired cysteine and the generation of RET dimers. Cysteine ret proto-oncogene Homo sapiens
8 We describe a novel c.1765A > T variant of RET proto-oncogene in a family with medullary thyroid carcinoma (MTC) that predicts the creation of an additional cysteine p.(Ser589Cys) in the cysteine-rich domain. Cysteine ret proto-oncogene Homo sapiens
9 We describe a novel c.1765A > T variant of RET proto-oncogene in a family with medullary thyroid carcinoma (MTC) that predicts the creation of an additional cysteine p.(Ser589Cys) in the cysteine-rich domain. Cysteine ret proto-oncogene Homo sapiens