Pub. Date : 2021 Jul
PMID : 33081568
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | co-infusion of erlotinib and tariquidar by studying brain distribution of the model ABCB1/ABCG2 substrate [11C]erlotinib in mice and rhesus macaques with PET. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | Co-infusion of erlotinib/tariquidar may potentially allow for complete ABCB1/ABCG2 inhibition at the BBB, while simultaneously achieving brain-targeted EGFR inhibition. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |