Title : A thiamine-triggered fluormetric assay for acetylcholinesterase activity and inhibitor screening based on oxidase-like activity of MnO2 nanosheets.

Pub. Date : 2021 Jan 1

PMID : 33076048






2 Functional Relationships(s)
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1 This biosensor obtained a good linear range from 0.02 to 1 mU/mL and an extremely low detection limit of 15 muU/mL for AChE assay, as well as a sensitive screening for tacrine and an excellent applicability in human serum samples. Tacrine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Owing to the inhibiting effect of tacrine to the AChE activity, the decomposition of MnO2 was hindered, thus leading to the fluorescence recovery. Tacrine acetylcholinesterase (Cartwright blood group) Homo sapiens