Title : Beta-caryophyllene inhibits cocaine  addiction-related behavior by activation of PPARα and PPARγ: repurposing a FDA-approved food additive for cocaine use disorder.

Pub. Date : 2021 Mar

PMID : 33069159






2 Functional Relationships(s)
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1 Beta-caryophyllene inhibits cocaine self-administration by activation of PPARalpha and PPARgamma: repurposing a FDA-approved food additive for cocaine use disorder. caryophyllene peroxisome proliferator activated receptor gamma Mus musculus
2 Furthermore, pharmacological blockade of mu opioid receptor or Toll-like receptors complex failed to alter, while blockade of peroxisome proliferator-activated receptors (PPARalpha, PPARgamma) reversed BCP-induced reduction in cocaine self-administration, suggesting the involvement of PPARalpha and PPARgamma in BCP"s action. caryophyllene peroxisome proliferator activated receptor gamma Mus musculus