Pub. Date : 2020
PMID : 33061461
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Emodin Reverses Gemcitabine Resistance of Pancreatic Cancer Cell Lines Through Inhibition of IKKbeta/NF-kappaB Signaling Pathway. | Emodin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Emodin significantly reduced NF-kappaB activity and emodin significantly promoted P-gp fluorescence intensity from Rhodamine 123 efflux assay. | Emodin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Conclusion: Emodin inhibits the expression of IKKbeta, thereby inhibiting the expression and activity of downstream NF-kappaB, and inhibits P-gp function at the same time, ultimately achieving the purpose of reversing the drug-resistance of pancreatic cancer cell lines. | Emodin | nuclear factor kappa B subunit 1 | Homo sapiens |