Title : Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells.

Pub. Date : 2021 Feb 15

PMID : 33053467






1 Functional Relationships(s)
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1 In addition, SiO2 NPs were found to promote the translocation and release of high-mobility group box 1 (HMGB1) from nucleus to cytoplasm, which was demonstrated to be regulated by ROS and NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens