Title : Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study.

Pub. Date : 2022 Mar

PMID : 33047663






2 Functional Relationships(s)
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1 Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. Tacrine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. Tacrine acetylcholinesterase (Cartwright blood group) Homo sapiens