Pub. Date : 2020 Dec 17
PMID : 33041005
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced acute liver failure (ALF). | Galactosamine | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced acute liver failure (ALF). | Galactosamine | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | This study aims to investigate the role of NLRP3 inflammasome in D-GalN/LPS-induced fatal hepatitis. | Galactosamine | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | We found that Nlrp3-/- and WT mice showed similar mortality against a lethal dose of D-GalN/LPS treatment. | Galactosamine | NLR family, pyrin domain containing 3 | Mus musculus |
| 5 | Besides, Nlrp3-/- mice had reduced IL-1beta levels but similar TNF-alpha, IL-6, and MCP-1 levels compared with WT mice upon D-GalN/LPS administration. | Galactosamine | NLR family, pyrin domain containing 3 | Mus musculus |