Title : 1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1.

Pub. Date : 2020 Dec 1

PMID : 33035519






2 Functional Relationships(s)
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Protein Name
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1 1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1. 1-methylpyrene sulfotransferase family 1A member 1 Homo sapiens
2 The results indicated that 1-MP induced micronuclei in V79-hCYP1A2-hSULT1A1 cells from 0.125 to 2 muM under a 24 h/0 h (exposure/recovery) regime, while in the parental V79-Mz cells micronuclei were induced by 1-MP only at concentrations >= 8 muM; in both cases, the micronuclei induced by 1-MP were predominantly CENP-B positive. 1-methylpyrene sulfotransferase family 1A member 1 Homo sapiens