Title : Chemoproteomics-Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism.

Pub. Date : 2021 Feb 8

PMID : 33035395






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1 Specifically, we identify highly potent and selective photoswitchable inhibitors of the drug-metabolizing enzymes carboxylesterases 1 and 2 and demonstrate the pharmacological application of our compounds by optically controlling the metabolism of the immunosuppressant drug mycophenolate mofetil. Mycophenolic Acid carboxylesterase 1 Homo sapiens